“The greater surface area of nanoparticles for a given mass compared with larger particles of the same chemical composition has been associated with increased inflammogenic toxicity and tumorigenic responses in a a number of studies in experimental animals or cell systems.”1
1. P. Schulte, C. Geraci, R. Zumwalde, M. Hoover, and E. Kuempel, “Occupational Risk Management of Engineered Nanoparticles,” Journal of Occupational and Environment Hygiene 5(4)239-249 (April 2008) .